SRIs and Psychedelics: A Guide to Understanding the Interaction

SSRIs and Psychedelics: A Guide to Understanding the Interaction

Selective serotonin reuptake inhibitors (SSRIs) and psychedelics are two classes of psychoactive substances that have become increasingly popular in recent years for their potential to alleviate symptoms of depression, anxiety, and other mental health conditions. However, these substances can interact in complex and potentially dangerous ways, and it is important to understand these interactions before combining them.

In this blog post, we will explore the interaction between SSRIs and psychedelics, including the risks and benefits of combining these substances, and the precautions that should be taken to ensure safe and effective use.

What are SSRIs?

Selective serotonin reuptake inhibitors, or SSRIs, are a class of antidepressant medications that work by increasing the levels of serotonin in the brain. Serotonin is a neurotransmitter that plays a key role in regulating mood, appetite, and sleep, among other functions.

Some commonly prescribed SSRIs include:

Fluoxetine (Prozac)
Sertraline (Zoloft)
Escitalopram (Lexapro)
Paroxetine (Paxil)
Citalopram (Celexa)
SSRIs are generally considered safe and effective for the treatment of depression and other mood disorders, but they can have side effects, such as nausea, insomnia, and sexual dysfunction.

What are Psychedelics?

Psychedelics are a class of psychoactive substances that can induce profound changes in perception, mood, and thought. Some commonly used psychedelics include:

LSD (lysergic acid diethylamide)
Psilocybin (found in “magic mushrooms”)
DMT (dimethyltryptamine)
Ayahuasca (a plant-based brew containing DMT)
Psychedelics are increasingly being studied for their potential therapeutic benefits in treating a variety of mental health conditions, including depression, anxiety, and post-traumatic stress disorder (PTSD).

However, psychedelics can also have serious risks, such as triggering psychotic episodes, exacerbating pre-existing mental health conditions, and causing physical harm in some cases.

What is the Interaction Between SSRIs and Psychedelics?

SSRIs and psychedelics both affect the levels of serotonin in the brain, but they do so in different ways. SSRIs work by blocking the reuptake of serotonin, effectively increasing its levels in the brain. Psychedelics, on the other hand, bind to serotonin receptors and mimic the effects of serotonin.

Because of these different mechanisms of action, the interaction between SSRIs and psychedelics can be complex and unpredictable. In some cases, the combination of these substances can lead to a dangerous condition called serotonin syndrome, which can cause symptoms such as:

Rapid heart rate
High blood pressure
Dilated pupils
Loss of muscle coordination
Muscle rigidity
Serotonin syndrome can be life-threatening and requires immediate medical attention.

Can SSRIs Affect the Effects of Psychedelics?

SSRIs can also affect the effects of psychedelics, potentially reducing their efficacy. Because SSRIs increase the levels of serotonin in the brain, they can reduce the potency of psychedelics, which rely on serotonin receptors to produce their effects.

This means that individuals taking SSRIs may need to take higher doses of psychedelics to achieve the desired effects, which can increase the risk of adverse reactions and make it more difficult to control the intensity and duration of the psychedelic experience.

Precautions for Combining SSRIs and Psychedelics

If you are taking SSRIs and are interested in trying psychedelics, it is important to take certain precautions to reduce the risks of adverse interactions. Here are some things to keep in mind:

Talk to your healthcare provider: Before trying psychedelics, talk to your healthcare provider about your current medications and any medical conditions you may have. They can provide guidance on whether it is safe for you to try psychedelics, and what precautions you should take.
Taper off SSRIs: If you are planning to take psychedelics, your healthcare provider may advise you to taper off your SSRIs for a period of time beforehand. This can help reduce the risk of serotonin syndrome and make it easier to achieve the desired effects of psychedelics.
Be cautious with dosing: If you do decide to try psychedelics while taking SSRIs, start with a low dose and proceed with caution. It is important to be mindful of the potential risks and to be prepared to seek medical attention if necessary.
Consider alternative treatments: If you are concerned about the risks of combining SSRIs and psychedelics, consider alternative treatments for depression and other mental health conditions, such as psychotherapy, exercise, and dietary changes.


SSRIs and psychedelics are two powerful tools for treating mental health conditions, but they can interact in complex and potentially dangerous ways. If you are considering trying psychedelics while taking SSRIs, it is important to talk to your healthcare provider and to take precautions to ensure safe and effective use.

While the combination of SSRIs and psychedelics may not be right for everyone, it is important to remember that there are many alternative treatments available for depression and other mental health conditions. By working with your healthcare provider and exploring all of your options, you can find the treatment plan that is right for you.